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Biochemistry and Molecular Biotechnology
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Our most recent publications
Total:
displaying 10 out of
19
results
The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition
Friday, November 29, 2024
Author(s):
Young-Cheul Shin,Ashlee Marie Plummer-Medeiros,Alison Mungenast,Hyeong-Wook Choi,Karen TenDyke,Xiaojie Zhu,Jennifer Shepard,Kristen Sanders,Ningning Zhuang,Liang Hu,Dongming Qian,Kangkang Song,Chen Xu,John Wang,Suresh B Poda,Maofu Liao,Yu Chen
Source:
Science advances
Structural basis of respiratory complex adaptation to cold temperatures
Saturday, October 12, 2024
Author(s):
Young-Cheul Shin,Pedro Latorre-Muro,Amina Djurabekova,Oleksii Zdorevskyi,Christopher F Bennett,Nils Burger,Kangkang Song,Chen Xu,Joao A Paulo,Steven P Gygi,Vivek Sharma,Maofu Liao,Pere Puigserver
Source:
Cell
Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition
Wednesday, September 04, 2024
Author(s):
Shuhui Wang,Kun Wang,Kangkang Song,Zon Weng Lai,Pengfei Li,Dongying Li,Yajie Sun,Ye Mei,Chen Xu,Maofu Liao
Source:
Nature communications
Structures of the essential efflux pump EfpA from Mycobacterium tuberculosis reveal the mechanisms of substrate transport and small-molecule inhibition
Tuesday, January 23, 2024
Author(s):
Shuhui Wang,Kun Wang,Kangkang Song,Pengfei Li,Dongying Li,Yajie Sun,Ye Mei,Chen Xu,Maofu Liao
Source:
Research square
Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing
Saturday, July 15, 2023
Author(s):
Steven D Tettoni,Shawn B Egri,Dylan D Doxsey,Kristen Veinotte,Christna Ouch,Jeng-Yih Chang,Kangkang Song,Chen Xu,Kuang Shen
Source:
Structure (London, England : 1993)
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane
Wednesday, June 07, 2023
Author(s):
Wei Shi,Yongfei Cai,Haisun Zhu,Hanqin Peng,Jewel Voyer,Sophia Rits-Volloch,Hong Cao,Megan L Mayer,Kangkang Song,Chen Xu,Jianming Lu,Jun Zhang,Bing Chen
Source:
Nature
Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis
Monday, May 29, 2023
Author(s):
Xuewu Sui,Kun Wang,Kangkang Song,Chen Xu,Jiunn Song,Chia-Wei Lee,Maofu Liao,Robert V Farese,Tobias C Walther
Source:
Nature communications
Structural basis for GSDMB pore formation and its targeting by IpaH7.8
Wednesday, March 29, 2023
Author(s):
Chengliang Wang,Sonia Shivcharan,Tian Tian,Skylar Wright,Danyang Ma,JengYih Chang,Kunpeng Li,Kangkang Song,Chen Xu,Vijay A Rathinam,Jianbin Ruan
Source:
Nature
Author Correction: Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Wednesday, September 28, 2022
Author(s):
Russell A Judge,Janani Sridar,Kathryn Tunyasuvunakool,Rinku Jain,John C K Wang,Christna Ouch,Jun Xu,Amirhossein Mafi,Aaron H Nile,Clint Remarcik,Corey L Smith,Crystal Ghosh,Chen Xu,Vincent Stoll,John Jumper,Amoolya H Singh,Dan Eaton,Qi Hao
Source:
Nature communications
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Tuesday, September 20, 2022
Author(s):
Russell A Judge,Janani Sridar,Kathryn Tunyasuvunakool,Rinku Jain,John C K Wang,Christna Ouch,Jun Xu,Amirhossein Mafi,Aaron H Nile,Clint Remarcik,Corey L Smith,Crystal Ghosh,Chen Xu,Vincent Stoll,John Jumper,Amoolya H Singh,Dan Eaton,Qi Hao
Source:
Nature communications
Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism
Saturday, March 26, 2022
Author(s):
Shawn B Egri,Christna Ouch,Hui-Ting Chou,Zhiheng Yu,Kangkang Song,Chen Xu,Kuang Shen
Source:
Molecular cell
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks
Tuesday, March 15, 2022
Author(s):
Qiuyu J Huang,Kangkang Song,Chen Xu,Daniel N A Bolon,Jennifer P Wang,Robert W Finberg,Celia A Schiffer,Mohan Somasundaran
Source:
Structure (London, England : 1993)
Comprehensive structure and functional adaptations of the yeast nuclear pore complex
Tuesday, January 04, 2022
Author(s):
Christopher W Akey,Digvijay Singh,Christna Ouch,Ignacia Echeverria,Ilona Nudelman,Joseph M Varberg,Zulin Yu,Fei Fang,Yi Shi,Junjie Wang,Daniel Salzberg,Kangkang Song,Chen Xu,James C Gumbart,Sergey Suslov,Jay Unruh,Sue L Jaspersen,Brian T Chait,Andrej Sali,Javier Fernandez-Martinez,Steven J Ludtke,Elizabeth Villa,Michael P Rout
Source:
Cell
Distinct allosteric mechanisms of first-generation MsbA inhibitors
Thursday, September 23, 2021
Author(s):
François A Thélot,Wenyi Zhang,KangKang Song,Chen Xu,Jing Huang,Maofu Liao
Source:
Science (New York, N.Y.)
Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins
Wednesday, August 04, 2021
Author(s):
Stuti Sharma,Ruoyu Zhou,Li Wan,Shan Feng,KangKang Song,Chen Xu,Yanyan Li,Maofu Liao
Source:
Nature communications
pH-Induced Conformational Changes of Human Bocavirus Capsids
Thursday, January 21, 2021
Author(s):
Mengxiao Luo,Mario Mietzsch,Paul Chipman,Kangkang Song,Chen Xu,John Spear,Duncan Sousa,Robert McKenna,Maria Söderlund-Venermo,Mavis Agbandje-McKenna
Source:
Journal of virology
Extensive ribosome and RF2 rearrangements during translation termination
Friday, September 13, 2019
Author(s):
Egor Svidritskiy,Gabriel Demo,Anna B Loveland,Chen Xu,Andrei A Korostelev
Source:
eLife
Structure of the Human Core Centromeric Nucleosome Complex
Tuesday, July 30, 2019
Author(s):
Praveen Kumar Allu,Jennine M Dawicki-McKenna,Trevor Van Eeuwen,Moriya Slavin,Merav Braitbard,Chen Xu,Nir Kalisman,Kenji Murakami,Ben E Black
Source:
Current biology : CB
Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics
Wednesday, August 27, 2014
Author(s):
Yi Kuang,Marcus J C Long,Jie Zhou,Junfeng Shi,Yuan Gao,Chen Xu,Lizbeth Hedstrom,Bing Xu
Source:
The Journal of biological chemistry
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