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Faculty
Research Focus: Understanding molecular mechanisms controlling inflammatory response
Sensing and signaling in innate immunity (TLRs, Inflammasomes, cGAS/STING)
Autoinflammatory diseases (e.g., SAVI - STING associated Vasculopathy with onset in Infancy)
Therapeutic targeting of Inflammasomes and cGAS/STING Signaling
Oral prophylaxis to prevent and treat enteric infections and gastrointestinal disorders
B cell regulation in autoimmunity and infectious disease
Epitope discovery to diagnose, prevent or treat infectious disease and cancer
Research Focus: Understanding host-pathogen interactions
Innate antiviral immunity and inflammation research
Identifying novel RNA binding proteins with viral RNAs for therapeutic targeting
Research Focus:
Antibody engineering and therapeutic protein design
Drug delivery across the blood-brain barrier for treatment of Alzheimer’s Disease
Antibody-drug conjugates as potential anti-viral agents
Research Focus: Innate immunity responses in host defense and autoimmunity
Biology of dendritic cell activation and regulation through the immunometabolism
Dendritic cell recognition of DAMPs and PAMPs
Role of innate immunity in the pathogenesis of autoimmunity
Innate immune responses to bacterial infections and biofilms
Novel therapeutic targets in lupus autoimmunity
Research Focus: How immunometabolism regulates infectious disease and inflammation
Regulation of cell death by oncometabolites
Macrophage receptor biology in tumorigenesis and metastasis
Mitochondrial reprogramming in "inflamm-aging"
Metabolic control of viral infections
Therapeutic targeting of innate immune signaling pathways
Research Focus: Late-stage clinical development of three human monoclonal antibodies to prevent Lyme disease, prevent ETEC disease, and treat diphtheria
Molecular pathogenesis of Lyme disease
Prevention and treatment of Lyme disease
Strategies to interrupt transmission of vector-transmitted infectious diseases
Oral IgA immune-based prevention and treatment of enterotoxigenic E.coli (ETEC) infections
Development of human monoclonal antibodies for the prevention and treatment of human diseases
Research Focus: Understanding human genetic variation and environmental factors (viruses and other pathogens) in neurological diseases
Developing human induced pluripotent stem cell based neuroinflammation systems for high-throughput assays
Identifying human-pathogen interactions in innate immunity for therapeutic identification
Developing multiplexed, high-throughput screens to reverse disease-associated molecular pathology
Research Focus: Developing translatable immunologic therapeutic agents
Translation of human biologics in animal models (e.g., the study of species-specific biology of Immunoglobulins, Fc Receptors, etc.)
Development of species-tailored immunomodulatory reagents
Genetic delivery of immunobiological therapies
Research Focus: Understanding the molecular mechanisms of tissue-specific immune responses
Metabolic/differentiation state of T cells
Contribution of metabolic state of tissues on T cell responses
Gut-microbiome and their metabolites on T cell responses
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