The Shaw lab studies the IGF-1R/insulin signaling pathway, with a focus on the Insulin Receptor Substrate (IRS) proteins and the mechanism by which these signaling adaptors regulate tumor progression.  The IRS proteins are essential for transmitting signals from the insulin and IGF-1 receptors to regulate growth and metabolic homeostasis in both normal and pathological settings.  Research in the Shaw lab investigates how the IRS proteins regulate tumor metabolism, as well as the tumor cell response to the metabolic microenvironment of tumors.

• Pankratz SL, Tan EY, Fine Y, Mercurio AM, Shaw LM. (2009) Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1. J Biol Chem. 284(4):2031-7.
• Mardilovich K, Shaw LM. (2009) Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion. Cancer Res. 69(23):8894-901.
• Landis J, Shaw LM. (2014) Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis. J Biol Chem. 289(26):18603-13.