Step 1 Content | Neoplasia

General Neoplasia

- Adenomas (glandular origin) - Lipomas (fat tissue) - Leiomyomas (smooth muscle) - Fibromas (connective tissue) - Hemangiomas (blood vessels)

- Carcinomas (epithelial origin: squamous cell, adenocarcinoma) - Sarcomas (mesenchymal origin) - Lymphomas (Hodgkin, non-Hodgkin) - Leukemias (myeloid, lymphoid) - Metastatic cancers (spread from primary site)

Hematopoietic & Lymphoreticular

- Benign lymphoid hyperplasia - Splenic hemangioma

- Leukemia (ALL, AML, CLL, CML) - Lymphoma (Hodgkin’s, Non-Hodgkin’s) - Multiple myeloma

Central & Peripheral Nervous

- Meningioma (meninges) - Schwannoma (nerve sheath) - Pituitary adenoma (hormone-secreting tumor)

- Glioblastoma multiforme (GBM) - Astrocytoma - Oligodendroglioma - Medulloblastoma (children)

Skin & Connective Tissue

- Seborrheic keratosis - Dermatofibroma - Lipoma (subcutaneous fat)

- Melanoma (aggressive, pigmented skin cancer) - Squamous cell carcinoma - Basal cell carcinoma - Kaposi sarcoma (HHV-8 related)

Musculoskeletal

- Osteochondroma (cartilage-capped bone tumor) - Giant cell tumor of bone

- Osteosarcoma (long bones, aggressive) - Ewing sarcoma (childhood bone cancer) - Chondrosarcoma (cartilage tumor)

Respiratory

- Pulmonary hamartoma (cartilage, connective tissue)

- Non-small cell lung carcinoma (adenocarcinoma, squamous cell carcinoma, large cell carcinoma) - Small cell lung carcinoma (highly aggressive) - Mesothelioma (asbestos-related pleural tumor)

Cardiovascular

- Cardiac myxoma (most common benign heart tumor)

- Angiosarcoma (malignant vascular tumor) - Hemangiosarcoma

Gastrointestinal

- Hepatic hemangioma (benign liver lesion) - Colonic adenoma (precancerous polyp) - Gastric leiomyoma

- Colorectal adenocarcinoma - Hepatocellular carcinoma (HCC) - Pancreatic adenocarcinoma - Gastric carcinoma

Renal/Urinary

- Renal oncocytoma - Angiomyolipoma (associated with tuberous sclerosis)

- Renal cell carcinoma (RCC) - Wilms tumor (pediatric kidney cancer) - Urothelial carcinoma (bladder cancer)

Reproductive

- Uterine leiomyoma (fibroids) - Ovarian cystadenoma - Benign prostatic hyperplasia (BPH)

- Cervical carcinoma (HPV-associated) - Ovarian carcinoma (serous, mucinous, clear cell) - Testicular cancer (seminoma, non-seminomatous germ cell tumors) - Prostate adenocarcinoma

Endocrine

- Thyroid adenoma (follicular adenoma) - Pituitary adenoma

- Thyroid carcinoma (papillary, follicular, medullary, anaplastic) - Adrenal cortical carcinoma - Pancreatic neuroendocrine tumor (insulinoma, glucagonoma)