Sep 15, 2023
Taking the STING out of Disease -Biochemistry & Molecular Biotechnology (BMB) Department
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We develop potent and selective inhibitors of proteins whose activities are involved in triggering human diseases.
Diseases like rheumatoid arthritis and cancer affect millions every year, and our studies could help alleviate human suffering by identifying new drugs.
Our lab uses kinetic and structural analyses to guide the design of small molecule inhibitors, which we then synthesize and evaluate as inhibitors.
We are a highly collaborative and social group of dedicated chemists and biologists.
Fuhrmann, J., Clancy, K., Thompson, P.R.
(2015) Rev. 115 , 5413-5461. PMC4463550
this links to a paper called Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation
Humphries, F., Shmuel-Galia, L., Jiang, Z., Zhou, J., Barasa, L., Mondal, S., Wilson, R, Sultana, N., Shaffer, S.A., Ng, S., Pesiridis, G.S., Thompson, P.R.* and Fitzgerald, K.A. *
(2023) Targeting STING oligomerization with small-molecule inhibitors. PNAS 120, e2305420120.
this links to a paper called Targeting STING oligomerization with small-molecule inhibitors
Mondal, S., Chen, Y., Lockbaum, G.J., Sen, S., Chaudhuri, S. Reyes, A.C., Lee, J.M., Kaur, A.N., Sultana, N. Cameron, M.D., Shaffer, S.A., Schiffer, C.A., Fitzgerald, K.A., and Thompson, P.R.
(2022) J. Am Chem Soc. 144, 21305-21045. PMID: 36356199. PMC9662648
this links to a paper called Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
Mondal, S., Wang, S., Zheng, Y., Sen, S., Chatterjee, A., and Thompson, P. R.
(2021) Nature Comm. 12, 45. PMID: 33398026
this links to a paper called Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
