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Aroian Lab
Publications
Publications
Total:
displaying 50 out of
97
results
Methyl-HLH-30/TFEB orchestrates holistic intestinal recuperation against bacterial pore-forming toxin intoxication via TTC38 in metazoans
Thursday, September 17, 2026
Author(s):
Hui-Chen Hsieh,Yi-Lin Cheng,Chyuan-Chuan Wu,Chee Kit Joshua Luk,Yi-Hsiu Weng,Tzu-Hsuan Chiu,Shao-Wen Chang,Ting-Wei Chang,Yan-Ning Gu,Jhen-Wei Ruan,Tzer-Min Lee,Shuying Wang,Po-Lin Chen,Raffi V Aroian,Chang-Shi Chen
Source:
Autophagy
Chromosomal markerless integration of anthelmintic Cry proteins into the Bacillus thuringiensis genome
Monday, May 04, 2026
Author(s):
Kelly A Flanagan,Nicholas Cazeault,Hanchen Li,Elizabeth Kass,Katherine L Petersson,Gary R Ostroff,Raffi V Aroian
Source:
bioRxiv : the preprint server for biology
Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system
Tuesday, March 17, 2026
Author(s):
Erich M Schwarz,Jason B Noon,Jeffrey D Chicca,Carli Garceau,Hanchen Li,Igor Antoshechkin,Vladislav Ilík,Barbora Pafčo,Amy M Weeks,E Jane Homan,Gary R Ostroff,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Catalytically Active Recombinant Cysteine Proteases of Haemonchus contortus: Their Ability to Degrade Host Blood Proteins and Modulate Coagulation
Tuesday, December 30, 2025
Author(s):
Athira C Karunakaran,Mariam Bakshi,Arunraj M Rajendrakumar,Jennifer H Wilson-Welder,Raffi V Aroian,Erich M Schwarz,E Jane Homan,Gary R Ostroff,Ethiopia Beshah,Eliseo Miramontes,Marianne Dias Papadopoulos,Scott A Bowdridge,Dante S Zarlenga,Xiaoping Zhu,Wenbin Tuo
Source:
International journal of molecular sciences
An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes
Tuesday, December 09, 2025
Author(s):
Kyriaki Neophytou,Isaac Martínez-Ugalde,Thomas M Fenton,Elaine Robertson,Lewis J Strachan,Vignesh Jayaraman,Yvonne Harcus,Chanel M Naar,David Wright,Daniel R G Price,Ruby White,Michael J Evans,José Roberto Bermúdez-Barrientos,Hanchen Li,Rick M Maizels,Raffi V Aroian,Alasdair J Nisbet,Cei Abreu-Goodger,Amy H Buck
Source:
EMBO reports
Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections
Tuesday, October 14, 2025
Author(s):
Mostafa A Elfawal,Victoria Banas,Bruce A Rosa,Matthew Mahoney,Emily Goetz,Paulina Chen,Raffi V Aroian,James W Janetka,Makedonka Mitreva
Source:
ACS infectious diseases
A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival
Wednesday, April 16, 2025
Author(s):
Kyriaki Neophytou,Isaac Martínez-Ugalde,Thomas Fenton,Elaine Robertson,Lewis J Strachan,Yvonne Harcus,Chanel M Naar,David Wright,Daniel R G Price,Ruby White,Michael J Evans,Jose R Bermúdez-Barrientos,Hanchen Li,Rick M Maizels,Raffi V Aroian,Alasdair J Nisbet,Cei Abreu-Goodger,Amy H Buck
Source:
bioRxiv : the preprint server for biology
Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system
Thursday, February 20, 2025
Author(s):
Erich M Schwarz,Jason B Noon,Jeffrey D Chicca,Carli Garceau,Hanchen Li,Igor Antoshechkin,Vladislav Ilík,Barbora Pafčo,Amy M Weeks,E Jane Homan,Gary R Ostroff,Raffi V Aroian
Source:
bioRxiv : the preprint server for biology
Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections
Monday, January 20, 2025
Author(s):
Victoria Banas,Mostafa A Elfawal,Bruce A Rosa,Matthew Mahoney,Jacquelyn Kauffman,Emily Goetz,Paulina Chen,Raffi V Aroian,Makedonka Mitreva,James W Janetka
Source:
ACS infectious diseases
High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites
Monday, December 09, 2024
Author(s):
Mostafa A Elfawal,Emily Goetz,Youmie Kim,Paulina Chen,Sergey N Savinov,Leonard Barasa,Paul R Thompson,Raffi V Aroian
Source:
ACS infectious diseases
High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites
Monday, November 18, 2024
Author(s):
Mostafa A Elfawal,Emily Goetz,You-Mie Kim,Paulina Chen,Sergey N Savinov,Leonard Barasa,Paul R Thompson,Raffi V Aroian
Source:
bioRxiv : the preprint server for biology
Bacillus thuringiensis Cry14A family proteins as novel anthelmintics against gastrointestinal nematode parasites
Friday, October 25, 2024
Author(s):
Duy Hoang,Kelly Flanagan,Qian Ding,Nicholas R Cazeault,Hanchen Li,Stefani Díaz-Valerio,Florentina Rus,Esther A Darfour,Elizabeth Kass,Katherine H Petersson,Martin K Nielsen,Heiko Liesegang,Gary R Ostroff,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway
Friday, October 18, 2024
Author(s):
Youmie Kim,Thanh-Thanh Nguyen,Daniel J Durning,Takao Ishidate,Ozkan Aydemir,Craig C Mello,Yan Hu,Theodore W Kahn,Raffi V Aroian
Source:
PLoS pathogens
The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole
Friday, May 17, 2024
Author(s):
Paul D E Williams,Matthew T Brewer,Raffi V Aroian,Alan P Robertson,Richard J Martin
Source:
PLoS pathogens
PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins
Tuesday, January 23, 2024
Author(s):
Hui-Chen Hsieh,I-Hsiang Huang,Shao-Wen Chang,Po-Lin Chen,Yu-Cheng Su,Shuying Wang,Wei-Jiun Tsai,Ping-Hung Chen,Raffi V Aroian,Chang-Shi Chen
Source:
Autophagy
The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole
Monday, December 04, 2023
Author(s):
Paul D E Williams,Matthew T Brewer,Raffi Aroian,Alan P Robertson,Richard J Martin
Source:
bioRxiv : the preprint server for biology
Anthelmintics V: Drugs, resistance, and vaccines
Wednesday, May 31, 2023
Author(s):
Raffi V Aroian,Alex Loukas,Richard J Martin
Source:
International journal for parasitology
An efficient method for viable cryopreservation and recovery of hookworms and other gastrointestinal nematodes in the laboratory
Thursday, May 18, 2023
Author(s):
Hanchen Li,David Gazzola,Yan Hu,Raffi V Aroian
Source:
International journal for parasitology
Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains
Monday, April 03, 2023
Author(s):
Amanda O Shaver,Janneke Wit,Clayton M Dilks,Timothy A Crombie,Hanchen Li,Raffi V Aroian,Erik C Andersen
Source:
PLoS pathogens
An efficient method for viable cryopreservation of hookworms and other gastrointestinal nematodes in the laboratory
Monday, February 13, 2023
Author(s):
Hanchen Li,David Gazzola,Yan Hu,Raffi V Aroian
Source:
bioRxiv : the preprint server for biology
A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins
Monday, November 14, 2022
Author(s):
Anand Sitaram,Yunqiang Yin,Tammy Zamaitis,Bo Zhang,Raffi V Aroian
Source:
PLoS pathogens
Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis
Wednesday, August 10, 2022
Author(s):
Jeffrey Chicca,Nicholas R Cazeault,Florentina Rus,Ambily Abraham,Carli Garceau,Hanchen Li,Samar M Atwa,Kelly Flanagan,Ernesto R Soto,Mary S Morrison,David Gazzola,Yan Hu,David R Liu,Martin K Nielsen,Joseph F Urban,Gary R Ostroff,Raffi V Aroian
Source:
Microbiology spectrum
C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens
Thursday, June 30, 2022
Author(s):
Shouyong Ju,Hanqiao Chen,Shaoying Wang,Jian Lin,Yanli Ma,Raffi V Aroian,Donghai Peng,Ming Sun
Source:
Communications biology
Nematode ascarosides attenuate mammalian type 2 inflammatory responses
Friday, February 25, 2022
Author(s):
Kenta Shinoda,Andrea Choe,Kiyoshi Hirahara,Masahiro Kiuchi,Kota Kokubo,Tomomi Ichikawa,Jason S Hoki,Akane S Suzuki,Neelanjan Bose,Judith A Appleton,Raffi V Aroian,Frank C Schroeder,Paul W Sternberg,Toshinori Nakayama
Source:
Proceedings of the National Academy of Sciences of the United States of America
Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases
Saturday, November 20, 2021
Author(s):
Mariam Bakshi,Wenbin Tuo,Raffi V Aroian,Dante Zarlenga
Source:
Parasites & vectors
Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release
Wednesday, June 02, 2021
Author(s):
Ernesto R Soto,Florentina Rus,Hanchen Li,Carli Garceau,Jeffrey Chicca,Mostafa Elfawal,David Gazzola,Martin K Nielsen,Joseph F Urban,Raffi V Aroian,Gary R Ostroff
Source:
Foods (Basel, Switzerland)
An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals
Friday, April 23, 2021
Author(s):
Joseph F Urban,Martin K Nielsen,David Gazzola,Yue Xie,Ethiopia Beshah,Yan Hu,Hanchen Li,Florentina Rus,Kelly Flanagan,Austin Draper,Sridhar Vakalapudi,Robert W Li,Gary R Ostroff,Raffi V Aroian
Source:
One health (Amsterdam, Netherlands)
Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans
Tuesday, December 15, 2020
Author(s):
Hanchen Li,Ambily Abraham,David Gazzola,Yan Hu,Gillian Beamer,Kelly Flanagan,Ernesto Soto,Florentina Rus,Zeynep Mirza,Austin Draper,Sridhar Vakalapudi,Cheryl Stockman,Perry Bain,Joseph F Urban,Gary R Ostroff,Raffi V Aroian
Source:
Antimicrobial agents and chemotherapy
A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep
Thursday, November 26, 2020
Author(s):
John Sanders,Yue Xie,David Gazzola,Hanchen Li,Ambily Abraham,Kelly Flanagan,Florentina Rus,Melanie Miller,Yan Hu,Sierra Guynn,Austin Draper,Sridhar Vakalapudi,Katherine H Petersson,Dante Zarlenga,Robert W Li,Joseph F Urban,Gary R Ostroff,Anne Zajac,Raffi V Aroian
Source:
International journal for parasitology. Drugs and drug resistance
Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes
Thursday, July 02, 2020
Author(s):
Zeynep Mirza,Ernesto R Soto,Yan Hu,Thanh-Thanh Nguyen,David Koch,Raffi V Aroian,Gary R Ostroff
Source:
Molecules (Basel, Switzerland)
Gut microbial signatures associated with moxidectin treatment efficacy of Haemonchus contortus in infected goats
Wednesday, March 04, 2020
Author(s):
Fang Liu,Yue Xie,Anne M Zajac,Yan Hu,Raffi V Aroian,Joseph F Urban,Robert W Li
Source:
Veterinary microbiology
Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro
Saturday, September 14, 2019
Author(s):
Sarit Charuchaibovorn,Vivornpun Sanprasert,Nataya Sutthanont,Yan Hu,Ambily Abraham,Gary R Ostroff,Raffi V Aroian,Tegegn G Jaleta,James B Lok,Surang Nuchprayoon
Source:
The American journal of tropical medicine and hygiene
Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes
Wednesday, August 28, 2019
Author(s):
Mostafa A Elfawal,Sergey N Savinov,Raffi V Aroian
Source:
Scientific reports
Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics
Wednesday, June 26, 2019
Author(s):
Rahul Tyagi,Mostafa A Elfawal,Scott A Wildman,Jon Helander,Christina A Bulman,Judy Sakanari,Bruce A Rosa,Paul J Brindley,James W Janetka,Raffi V Aroian,Makedonka Mitreva
Source:
Scientific reports
Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters
Wednesday, May 29, 2019
Author(s):
Samuel C Pan,Doyle V Ward,Yunqiang Yin,Yan Hu,Mostafa A Elfawal,Robert E Clark,Raffi V Aroian
Source:
Scientific reports
A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection
Tuesday, April 23, 2019
Author(s):
Jason B Noon,Erich M Schwarz,Gary R Ostroff,Raffi V Aroian
Source:
PLoS neglected tropical diseases
In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites
Saturday, May 19, 2018
Author(s):
Yan Hu,Melanie Miller,Bo Zhang,Thanh-Thanh Nguyen,Martin K Nielsen,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure
Friday, May 18, 2018
Author(s):
Yan Hu,Thanh-Thanh Nguyen,Alice C Y Lee,Joseph F Urban,Melanie M Miller,Bin Zhan,David J Koch,Jason B Noon,Ambily Abraham,Ricardo Toshio Fujiwara,Dwight D Bowman,Gary R Ostroff,Raffi V Aroian
Source:
International journal for parasitology. Drugs and drug resistance
Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics
Thursday, May 03, 2018
Author(s):
Rahul Tyagi,Amarendar Reddy Maddirala,Mostafa Elfawal,Chelsea Fischer,Christina A Bulman,Bruce A Rosa,Xin Gao,Ryan Chugani,Mingzhou Zhou,Jon Helander,Paul J Brindley,Chih-Chung Tseng,Iain R Greig,Judy Sakanari,Scott A Wildman,Raffi Aroian,James W Janetka,Makedonka Mitreva
Source:
ACS infectious diseases
A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen
Friday, January 19, 2018
Author(s):
Marina Papaiakovou,Nils Pilotte,Ben Baumer,Jessica Grant,Kristjana Asbjornsdottir,Fabian Schaer,Yan Hu,Raffi Aroian,Judd Walson,Steven A Williams
Source:
PLoS neglected tropical diseases
Recombinant subunit vaccines for soil-transmitted helminths
Friday, August 04, 2017
Author(s):
Jason B Noon,Raffi V Aroian
Source:
Parasitology
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans
Wednesday, November 23, 2016
Author(s):
Huan-Da Chen,Cheng-Yuan Kao,Bang-Yu Liu,Shin-Whei Huang,Cheng-Ju Kuo,Jhen-Wei Ruan,Yen-Hung Lin,Cheng-Rung Huang,Yu-Hung Chen,Horng-Dar Wang,Raffi V Aroian,Chang-Shi Chen
Source:
Autophagy
The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins
Thursday, September 01, 2016
Author(s):
Alexey Dementiev,Jason Board,Anand Sitaram,Timothy Hey,Matthew S Kelker,Xiaoping Xu,Yan Hu,Cristian Vidal-Quist,Vimbai Chikwana,Samantha Griffin,David McCaskill,Nick X Wang,Shao-Ching Hung,Michael K Chan,Marianne M Lee,Jessica Hughes,Alice Wegener,Raffi V Aroian,Kenneth E Narva,Colin Berry
Source:
BMC biology
Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic
Sunday, December 20, 2015
Author(s):
Evelyn Durmaz,Yan Hu,Raffi V Aroian,Todd R Klaenhammer
Source:
Applied and environmental microbiology
eIF2α Confers Cellular Tolerance to S. aureus α-Toxin
Wednesday, August 19, 2015
Author(s):
Gisela von Hoven,Claudia Neukirch,Martina Meyenburg,Sabine Füser,Maria Bidna Petrivna,Amable J Rivas,Alexey Ryazanov,Randal J Kaufman,Raffi V Aroian,Matthias Husmann
Source:
Frontiers in immunology
Erratum: the genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families
Friday, May 29, 2015
Author(s):
Erich M Schwarz,Yan Hu,Igor Antoshechkin,Melanie M Miller,Paul W Sternberg,Raffi V Aroian
Source:
Nature genetics
Protection and Delivery of Anthelmintic Protein Cry5B to Nematodes Using Mesoporous Silicon Particles
Friday, May 08, 2015
Author(s):
Chia-Chen Wu,Yan Hu,Melanie Miller,Raffi V Aroian,Michael J Sailor
Source:
ACS nano
The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families
Tuesday, March 03, 2015
Author(s):
Erich M Schwarz,Yan Hu,Igor Antoshechkin,Melanie M Miller,Paul W Sternberg,Raffi V Aroian
Source:
Nature genetics
Nitazoxanide: nematicidal mode of action and drug combination studies
Tuesday, January 14, 2014
Author(s):
Vishal S Somvanshi,Brian L Ellis,Yan Hu,Raffi V Aroian
Source:
Molecular and biochemical parasitology
Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis
Wednesday, December 25, 2013
Author(s):
Sarah E Franks,Celia Ebrahimi,Andrew Hollands,Cheryl Y Okumura,Raffi V Aroian,Victor Nizet,Shauna M McGillivray
Source:
Infection and immunity
An extensive comparison of the effect of anthelmintic classes on diverse nematodes
Tuesday, July 23, 2013
Author(s):
Yan Hu,Brian L Ellis,Ying Y Yiu,Melanie M Miller,Joseph F Urban,Linda Z Shi,Raffi V Aroian
Source:
PloS one
Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases
Wednesday, July 10, 2013
Author(s):
Yan Hu,Melanie M Miller,Alan I Derman,Brian L Ellis,Rose Gomes Monnerat,Joe Pogliano,Raffi V Aroian
Source:
Applied and environmental microbiology
Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum
Wednesday, July 03, 2013
Author(s):
Joseph F Urban,Yan Hu,Melanie M Miller,Ulrike Scheib,Ying Y Yiu,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Role of pore-forming toxins in bacterial infectious diseases
Friday, May 24, 2013
Author(s):
Ferdinand C O Los,Tara M Randis,Raffi V Aroian,Adam J Ratner
Source:
Microbiology and molecular biology reviews : MMBR
Neuronal Goα and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins
Saturday, January 26, 2013
Author(s):
Ferdinand C O Los,Christine Ha,Raffi V Aroian
Source:
PloS one
Structure and glycolipid binding properties of the nematicidal protein Cry5B
Friday, November 16, 2012
Author(s):
Fan Hui,Ulrike Scheib,Yan Hu,Ralf J Sommer,Raffi V Aroian,Partho Ghosh
Source:
Biochemistry
Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms
Tuesday, November 13, 2012
Author(s):
Yan Hu,Bin Zhan,Brian Keegan,Ying Y Yiu,Melanie M Miller,Kathryn Jones,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Bacterial pore-forming proteins as anthelmintics
Tuesday, May 08, 2012
Author(s):
Yan Hu,Raffi V Aroian
Source:
Invertebrate neuroscience : IN
The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans
Thursday, January 05, 2012
Author(s):
Melanie F Kho,Audrey Bellier,Venkatasamy Balasubramani,Yan Hu,Wayne Hsu,Christina Nielsen-LeRoux,Shauna M McGillivray,Victor Nizet,Raffi V Aroian
Source:
PloS one
Global functional analyses of cellular responses to pore-forming toxins
Thursday, March 17, 2011
Author(s):
Cheng-Yuan Kao,Ferdinand C O Los,Danielle L Huffman,Shinichiro Wachi,Nicole Kloft,Matthias Husmann,Valbona Karabrahimi,Jean-Louis Schwartz,Audrey Bellier,Christine Ha,Youn Sagong,Hui Fan,Partho Ghosh,Mindy Hsieh,Chih-Shen Hsu,Li Chen,Raffi V Aroian
Source:
PLoS pathogens
RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin
Wednesday, February 16, 2011
Author(s):
Ferdinand C O Los,Cheng-Yuan Kao,Jane Smitham,Kent L McDonald,Christine Ha,Christina A Peixoto,Raffi V Aroian
Source:
Cell host & microbe
Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants
Wednesday, August 18, 2010
Author(s):
Keir M Balla,Geanncarlo Lugo-Villarino,Jan M Spitsbergen,David L Stachura,Yan Hu,Karina Bañuelos,Octavio Romo-Fewell,Raffi V Aroian,David Traver
Source:
Blood
ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis
Friday, April 09, 2010
Author(s):
Shauna M McGillivray,Celia M Ebrahimi,Nathan Fisher,Mojgan Sabet,Dawn X Zhang,Yahua Chen,Nina M Haste,Raffi V Aroian,Richard L Gallo,Donald G Guiney,Arthur M Friedlander,Theresa M Koehler,Victor Nizet
Source:
Journal of innate immunity
Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility
Wednesday, March 17, 2010
Author(s):
Yan Hu,Edward G Platzer,Audrey Bellier,Raffi V Aroian
Source:
Proceedings of the National Academy of Sciences of the United States of America
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans
Tuesday, March 09, 2010
Author(s):
Chang-Shi Chen,Audrey Bellier,Cheng-Yuan Kao,Ya-Luen Yang,Huan-Da Chen,Ferdinand C O Los,Raffi V Aroian
Source:
PloS one
Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice
Tuesday, March 09, 2010
Author(s):
Yan Hu,Sophia B Georghiou,Alan J Kelleher,Raffi V Aroian
Source:
PLoS neglected tropical diseases
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans
Thursday, December 17, 2009
Author(s):
Audrey Bellier,Chang-Shi Chen,Cheng-Yuan Kao,Hediye N Cinar,Raffi V Aroian
Source:
PLoS pathogens
The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist
Wednesday, August 12, 2009
Author(s):
Yan Hu,Shu-Hua Xiao,Raffi V Aroian
Source:
PLoS neglected tropical diseases
A Free-living Panagrolaimus sp. from Armenia Can Survive in Anhydrobiosis for 8.7 Years
Friday, March 13, 2009
Author(s):
R V Aroian,L Carta,I Kaloshian,P W Sternberg
Source:
Journal of nematology
Nervous about immunity: neuronal signals control innate immune system
Saturday, November 15, 2008
Author(s):
Cheng-Yuan Kao,Ferdinand C O Los,Raffi V Aroian
Source:
Nature immunology
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo
Saturday, October 11, 2008
Author(s):
Larry J Bischof,Cheng-Yuan Kao,Ferdinand C O Los,Manuel R Gonzalez,Zhouxin Shen,Steven P Briggs,F Gisou van der Goot,Raffi V Aroian
Source:
PLoS pathogens
Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans
Tuesday, May 08, 2007
Author(s):
Brad D Barrows,Joel S Griffitts,Raffi V Aroian
Source:
Journal of invertebrate pathology
Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein
Wednesday, April 25, 2007
Author(s):
Xiang-Qian Li,Jun-Zhi Wei,Anderson Tan,Raffi V Aroian
Source:
Plant biotechnology journal
Pore-forming toxins and cellular non-immune defenses (CNIDs)
Saturday, January 20, 2007
Author(s):
Raffi Aroian,F G van der Goot
Source:
Current opinion in microbiology
Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose
Friday, December 01, 2006
Author(s):
Brad D Barrows,Stuart M Haslam,Larry J Bischof,Howard R Morris,Anne Dell,Raffi V Aroian
Source:
The Journal of biological chemistry
Caenorhabditis elegans carbohydrates in bacterial toxin resistance
Thursday, November 30, 2006
Author(s):
Brad D Barrows,Joel S Griffitts,Raffi V Aroian
Source:
Methods in enzymology
A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
Friday, September 29, 2006
Author(s):
Michael Cappello,Richard D Bungiro,Lisa M Harrison,Larry J Bischof,Joel S Griffitts,Brad D Barrows,Raffi V Aroian
Source:
Proceedings of the National Academy of Sciences of the United States of America
Assays for toxicity studies in C. elegans with Bt crystal proteins
Friday, September 22, 2006
Author(s):
Larry J Bischof,Danielle L Huffman,Raffi V Aroian
Source:
Methods in molecular biology (Clifton, N.J.)
Many roads to resistance: how invertebrates adapt to Bt toxins
Saturday, May 14, 2005
Author(s):
Joel S Griffitts,Raffi V Aroian
Source:
BioEssays : news and reviews in molecular, cellular and developmental biology
Glycolipids as receptors for Bacillus thuringiensis crystal toxin
Saturday, February 12, 2005
Author(s):
Joel S Griffitts,Stuart M Haslam,Tinglu Yang,Stephan F Garczynski,Barbara Mulloy,Howard Morris,Paul S Cremer,Anne Dell,Michael J Adang,Raffi V Aroian
Source:
Science (New York, N.Y.)
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins
Saturday, July 17, 2004
Author(s):
Danielle L Huffman,Laurence Abrami,Roman Sasik,Jacques Corbeil,F Gisou van der Goot,Raffi V Aroian
Source:
Proceedings of the National Academy of Sciences of the United States of America
Pore worms: using Caenorhabditis elegans to study how bacterial toxins interact with their target host
Thursday, May 20, 2004
Author(s):
Danielle L Huffman,Larry J Bischof,Joel S Griffitts,Raffi V Aroian
Source:
International journal of medical microbiology : IJMM
Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity
Tuesday, October 07, 2003
Author(s):
Chad A Rappleye,Akiko Tagawa,Nathalie Le Bot,Julie Ahringer,Raffi V Aroian
Source:
BMC developmental biology
Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions
Friday, August 29, 2003
Author(s):
Joel S Griffitts,Danielle L Huffman,Johanna L Whitacre,Brad D Barrows,Lisa D Marroquin,Reto Müller,Jillian R Brown,Thierry Hennet,Jeffrey D Esko,Raffi V Aroian
Source:
The Journal of biological chemistry
Bacillus thuringiensis crystal proteins that target nematodes
Tuesday, February 25, 2003
Author(s):
Jun-Zhi Wei,Kristina Hale,Lynn Carta,Edward Platzer,Cynthie Wong,Su-Chiung Fang,Raffi V Aroian
Source:
Proceedings of the National Academy of Sciences of the United States of America
The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation
Friday, February 08, 2002
Author(s):
Chad A Rappleye,Akiko Tagawa,Rebecca Lyczak,Bruce Bowerman,Raffi V Aroian
Source:
Developmental cell
Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme
Saturday, August 04, 2001
Author(s):
J S Griffitts,J L Whitacre,D E Stevens,R V Aroian
Source:
Science (New York, N.Y.)
Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo
Saturday, May 05, 2001
Author(s):
A Tagawa,C A Rappleye,R V Aroian
Source:
Developmental biology
Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans
Saturday, August 05, 2000
Author(s):
L D Marroquin,D Elyassnia,J S Griffitts,J S Feitelson,R V Aroian
Source:
Genetics
The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans
Thursday, November 11, 1999
Author(s):
C A Rappleye,A R Paredez,C W Smith,K L McDonald,R V Aroian
Source:
Genes & development
Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo
Tuesday, April 01, 1997
Author(s):
R V Aroian,C Field,G Pruliere,C Kenyon,B M Alberts
Source:
The EMBO journal
Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function
Saturday, January 15, 1994
Author(s):
R V Aroian,G M Lesa,P W Sternberg
Source:
The EMBO journal
Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site
Friday, January 01, 1993
Author(s):
R V Aroian,A D Levy,M Koga,Y Ohshima,J M Kramer,P W Sternberg
Source:
Molecular and cellular biology
Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction
Saturday, June 01, 1991
Author(s):
R V Aroian,P W Sternberg
Source:
Genetics
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
Thursday, December 20, 1990
Author(s):
R V Aroian,M Koga,J E Mendel,Y Ohshima,P W Sternberg
Source:
Nature
The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans
Saturday, December 01, 1990
Author(s):
M Han,R V Aroian,P W Sternberg
Source:
Genetics
Interplanetary magnetic field enhancements and their association with the asteroid 2201 oljato
Friday, October 05, 1984
Author(s):
C T Russell,R Aroian,M Arghavani,K Nock
Source:
Science (New York, N.Y.)
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