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Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
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Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
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Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
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Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Additional Resources

Paul D. Kaufman, PhD

Professor, Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School

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Paul D. Kaufman, PhD

Research Focus - Chromatin Proteins That Regulate Genome Stability

Chromatin assembly factor-1 (CAF-1) regulation of the cellular localization of the tumor proliferation antigen protein Ki-67 throughout the cell cycle
Regulation of Ki67 mediated by a separate domain of CAF-1 independent of its canonical histone deposition activity
Ki-67 regulation of heterochromatin localization and modification
Contribution of Ki-67 to genome stability, the loss of which causes DNA damage checkpoint activation

Representative Publication

Garwain O, Sun X, Iyer DR, et al. The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage. Proc Natl Acad Sci USA. 2021;118(32):e2021998118.

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In the News

Getting Results…

UMMS scientists to expand 4D nucleome research with $13 million NIH grants

Investigators at UMass Medical School have received two, five-year grants totaling $13 million to explore how the 4D genome structure influences gene expression, cellular function, development and disease as it reshapes itself. Job Dekker, PhD, and Paul Kaufman, PhD, to investigate architecture of genome as it changes over time.

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