Cancer Genetics

The Cancer Genetics (CG) Program is a basic science program centered on determining how mutations in—and altered expression of—specific genes contribute to cancer development, progression and treatment. Research in the CG Program aims to:

• Identify and characterize genes that promote or prevent cancer and can affect treatment by, for example, mediating drug resistance or immune evasion
• Determine the basis by which specific genes become aberrantly expressed or silenced during cancer development and how this dysregulation contributes to the neoplastic phenotype
• Develop and utilize novel animal model systems to study the impact of key genetic alterations found in human cancers