Paul D. Kaufman, PhD
Research Focus - Chromatin Proteins That Regulate Genome Stability
- Chromatin assembly factor-1 (CAF-1) regulation of the cellular localization of the tumor proliferation antigen protein Ki-67 throughout the cell cycle
- Regulation of Ki67 mediated by a separate domain of CAF-1 independent of its canonical histone deposition activity
- Ki-67 regulation of heterochromatin localization and modification
- Contribution of Ki-67 to genome stability, the loss of which causes DNA damage checkpoint activation
Representative Publication
Garwain O, Sun X, Iyer DR, et al. The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage. Proc Natl Acad Sci USA. 2021;118(32):e2021998118.