Research in the Guertin Lab 

We study how cells sense and respond to nutrients, focusing on the biochemical pathways that regulate metabolism in health and disease. Our research centers on the in sulinand mTOR pathways and their roles in conditions such as type 2 diabetes and cancer. We also investigate how adipose tissue senses, stores, and mobilizes energy while communicating with other organs to maintain metabolic balance.

Our goal is to identify key therapeutic targets to improve metabolic health and extend healthspan.

Nutrient Sensing & Metabolic Signaling 

We are interested in defining how nutrient sensing pathways—particularly mTOR and related networks—integratediverse metabolic cues to regulate cellular function. By studying how metabolites act not only as fuels but also as signaling molecules, we aim to uncover fundamental principles by which cells interpret their nutritional environment and adapt to changing physiological demands.

Metabolic State Control in Tissues

Tissues must continually shift between storing and using energy to keep the body’s metabolism in balance.

We study how these states are created, sustained, and adapted within and between tissues, with a focus on fat biology and mitochondrial function. Our research aims to understand how differences among cells, tissue structure, and environmental factors influence metabolic flexibility—and how disruptions in these systems lead to imbalances in energy regulation.

Metabolism in Disease & Therapeutic Targeting

Our research is examining how dysregulated metabolic pathways contribute to chronic conditions including obesity, cardiometabolic disease, polycystic kidney disease, and cancer. By identifying key regulatory nodes that govern metabolic function, we aim to develop strategies to therapeutically reprogram metabolism—restoring tissue function and improving systemic health without disrupting essential physiological processes.