Jul 31, 2024
Celebrating RNA Day with Dr. Thoru Pederson
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We study protein kinase regulatory networks that control signal transduction and cell cycle progression.
Our studies will contribute to our general understanding of signaling regulatory networks and protein-protein interactions, with relevance to the mechanisms underlying normal cell function as well as disease states.
We investigate these cellular behaviors using budding yeast (S.cerevisiae), which provides a model system that is highly amenable to experimentation using genetics, biochemistry, and cell biology.
We are a tight-knit group of scientists working together to advance our fundamental understanding of intracellular regulatory mechanisms.
Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo.
Bandyopadhyay S, Bhaduri S, Örd M, Davey NE, Loog M, Pryciak PM.
Curr Biol. 2020 Nov 16;30(22):4454-4466.e5. doi: 10.1016/j.cub.2020.08.099. Epub 2020 Sep 24. PMID: 32976810; PMCID: PMC8009629.
this links to a paper called Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo
A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs
Mythili S. Subbanna, Matthew J. Winters, Mihkel Örd, Norman E. Davey, and Peter M. Pryciak
bioRxiv 2024.10.30.621084; doi: https://doi.org/10.1101/2024.10.30.621084
this links to a paper called MAPK modulation of yeast pheromone signaling output and the role of phosphorylation sites in the scaffold protein Ste5
High-throughput discovery and deep characterization of cyclin-CDK docking motifs
Mihkel Örd, Matthew J. Winters, Mythili S. Subbanna, Natalia de Martin Garrido, Victoria I. Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J. Greber, Peter M. Pryciak*, Norman E. Davey*
bioRxiv 2024.12.03.625240; doi: https://doi.org/10.1101/2024.12.03.625240
