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Kara Smith, MD, publication report from PubMed

Total: 20 results

  • Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

    Monday, March 31, 2025
    Author(s): Meritxell Oliva,Mrinal K Sarkar,Michael E March,Amir Hossein Saeidian,Frank D Mentch,Chen-Lin Hsieh,Fanying Tang,Ranjitha Uppala,Matthew T Patrick,Qinmengge Li,Rachael Bogle,J Michelle Kahlenberg,Deborah Watson,Joseph T Glessner,Leila Youssefian,Hassan Vahidnezhad,Lam C Tsoi,Hakon Hakonarson,Johann E Gudjonsson,Kathleen M Smith,Bridget Riley-Gillis
    Source: Nature communications
    Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to atopic dermatitis genetic association studies are poised to boost power to detect genetic signal and identify loci contributing to atopic dermatitis risk. Here, we present a multi-ancestry GWAS meta-analysis of twelve atopic dermatitis cohorts from five ancestral populations totaling 56,146 cases and 602,280 controls. We report 101 genomic loci...

  • Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning

    Monday, March 31, 2025
    Author(s): Hon Wah Yeung,Colin R Buchanan,Joanna Moodie,Ian J Deary,Elliot M Tucker-Drob,Mark E Bastin,Heather C Whalley,Keith M Smith,Simon R Cox
    Source: bioRxiv : the preprint server for biology
    In this work, we propose a new class of graph measures for weighted connectivity information in the human brain based on node relative strengths: relative strength variability (RSV), measuring susceptibility to targeted attacks, and hierarchical RSV (hRSV), a first weighted statistical complexity measure for networks. Using six different network weights for structural connectomes from the UK Biobank, we conduct comprehensive analyses to explore relationships between the RSV and hRSV, and (i)...

  • Correction: Stochastic Models of Zoonotic Avian Influenza with Multiple Hosts, Environmental Transmission, and Migration in the Natural Reservoir

    Monday, March 24, 2025
    Author(s): Rowan L Hassman,Iona M H McCabe,Kaia M Smith,Linda J S Allen
    Source: Bulletin of mathematical biology
    No abstract

  • Assessing a Statewide Nursing Home Staffing Program through Quantitative and Qualitative Survey Data

    Tuesday, February 25, 2025
    Author(s): Lindsay J Peterson,Kelly M Smith
    Source: Journal of the American Medical Directors Association
    CONCLUSIONS AND IMPLICATIONS: Success of the PCA program in easing staffing challenges may have depended on administrators being proactive, in contrast to those who negatively assessed the program and took a more passive approach. Results provide evidence of differing leadership styles in the use of the PCA program, suggesting leadership training could better equip nursing home leaders to implement staffing initiatives. More research is recommended on the relationship between administrative...

  • Noninvasive Brain Stimulation as Focal Epilepsy Treatment in the Hospital, Clinic, and Home

    Thursday, February 20, 2025
    Author(s): Karimul Islam,Keith Starnes,Kelsey M Smith,Thomas Richner,Nicholas Gregg,Alejandro A Rabinstein,Gregory A Worrell,Brian N Lundstrom
    Source: medRxiv : the preprint server for health sciences
    CONCLUSIONS: TMS and tDCS are potential treatment approaches for drug resistant focal epilepsy patients in the hospital, clinic, and home. They have a favorable safety profile and can lead to a reduction in IEDs rates and seizures. These results suggest further studies are needed to examine NIBS as treatment for epilepsy.

  • Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes

    Thursday, January 30, 2025
    Author(s): Samantha E Sloane,Shashank P Sancheti,Moataz S Hendy,Kathryn M Smith,Raviraj Ananda Thorat,Hathaithep Senkum,Joseph R Clark
    Source: Organic letters
    Construction of vinylsilane building blocks is important for advancing the synthesis of complex small molecules and natural products. Herein, we report a highly regio- and stereoselective copper-catalyzed hydrosilylation of unsymmetrical internal aryl alkynes. The reaction is performed across a broad scope of internal aryl alkynes, providing exclusive access to α-vinylsilane alkenyl arene products, including several silylated small molecule drug analogs.

  • Multiwavelength constraints on the origin of a nearby repeating fast radio burst source in a globular cluster

    Monday, January 27, 2025
    Author(s): Aaron B Pearlman,Paul Scholz,Suryarao Bethapudi,Jason W T Hessels,Victoria M Kaspi,Franz Kirsten,Kenzie Nimmo,Laura G Spitler,Emmanuel Fonseca,Bradley W Meyers,Ingrid H Stairs,Chia Min Tan,Mohit Bhardwaj,Shami Chatterjee,Amanda M Cook,Alice P Curtin,Fengqiu Adam Dong,Tarraneh Eftekhari,B M Gaensler,Tolga Güver,Jane Kaczmarek,Calvin Leung,Kiyoshi W Masui,Daniele Michilli,Thomas A Prince,Ketan R Sand,Kaitlyn Shin,Kendrick M Smith,Shriharsh P Tendulkar
    Source: Nature astronomy
    The precise origins of fast radio bursts (FRBs) remain unknown. Multiwavelength observations of nearby FRB sources can provide important insights into the enigmatic FRB phenomenon. Here we present results from a sensitive, broadband X-ray and radio observational campaign of FRB 20200120E, the closest known extragalactic repeating FRB source (located 3.63 Mpc away in an ~10-Gyr-old globular cluster). We place deep limits on the persistent and prompt X-ray emission from FRB 20200120E, which we use...

  • Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two Paenibacillus spp. Isolates from a Gray Wolf (Canis lupus) Gastrointestinal Tract

    Friday, January 24, 2025
    Author(s): Jessika L Bryant,Jennifer McCabe,C Cristoph Klews,MiCayla Johnson,Ariel N Atchley,Thomas W Cousins,Maya Barnard-Davidson,Kristina M Smith,Mark R Ackermann,Michael Netherland,Nur A Hasan,Peter A Jordan,Evan S Forsythe,Patrick N Ball,Bruce S Seal
    Source: Veterinary sciences
    Inflammatory bowel disease (IBD) is increasing among mammals around the world, and domestic dogs are no exception. There is no approved cure for canine IBD with limited treatment options. Novel probiotic bacteria discovery from free-ranging animals for the treatment of IBD in domestic pets can likely yield promising probiotic candidates. Consequently, the overall aim was to isolate bacteria from free-ranging animals that could potentially be utilized as novel probiotics. Two bacteria identified...

  • Seizures and status epilepticus in anti-NMDA receptor encephalitis

    Wednesday, January 08, 2025
    Author(s): Ashar M Farooqi,Ahmad Sawalha,Shirin Jamal Omidi,Divyanshu Dubey,Jeffrey Britton,Kelsey M Smith
    Source: Journal of neurology
    BACKGROUND: Seizures, including status epilepticus (SE), are common in anti-NMDA receptor encephalitis (NMDARE). We aimed to describe clinical and electrographic features of patients with seizures with NMDARE, determine factors associated with SE, and describe long-term seizure outcomes.

  • 51-Year-Old Woman With Bilateral Facial Palsy and Lower Extremity Weakness

    Sunday, January 05, 2025
    Author(s): David O Sohutskay,Jacob D Goodwin,Kelsey M Smith
    Source: Mayo Clinic proceedings
    No abstract

  • FAST functional connectivity implicates P300 connectivity in working memory deficits in Alzheimer's disease

    Monday, December 30, 2024
    Author(s): Om Roy,Yashar Moshfeghi,Agustin Ibanez,Francisco Lopera,Mario A Parra,Keith M Smith
    Source: Network neuroscience (Cambridge, Mass.)
    Measuring transient functional connectivity is an important challenge in electroencephalogram (EEG) research. Here, the rich potential for insightful, discriminative information of brain activity offered by high-temporal resolution is confounded by the inherent noise of the medium and the spurious nature of correlations computed over short temporal windows. We propose a methodology to overcome these problems called filter average short-term (FAST) functional connectivity. First, a long-term,...

  • SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL), a Snakemate workflow for rapid and bulk analysis of Illumina sequencing of SARS-CoV-2 genomes

    Friday, December 20, 2024
    Author(s): Jalees A Nasir,Finlay Maguire,Kendrick M Smith,Emily M Panousis,Sheridan J C Baker,Patryk Aftanas,Amogelang R Raphenya,Brian P Alcock,Hassaan Maan,Natalie C Knox,Arinjay Banerjee,Karen Mossman,Bo Wang,Jared T Simpson,Robert A Kozak,Samira Mubareka,Andrew G McArthur
    Source: NAR genomics and bioinformatics
    The incorporation of sequencing technologies in frontline and public health healthcare settings was vital in developing virus surveillance programs during the Coronavirus Disease 2019 (COVID-19) pandemic caused by transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, increased data acquisition poses challenges for both rapid and accurate analyses. To overcome these hurdles, we developed the SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL) for quick bulk...

  • Reconstructing decision-making dynamics during public health crises by applying data science to public records

    Wednesday, December 18, 2024
    Author(s): Peter Nadel,Kevin M Smith
    Source: Journal of public health policy
    Public health policies can dramatically shape government responses to emerging public health crises. In cases where a response is inadequate, it's natural to seek improvements to these policies to achieve better results in future crises. However, while policies and outcomes are usually visible, the complex dynamics that link them are seldom obvious. Obscure social network structures, power and information asymmetries, and political agendas all influence the translation of policy to action or...

  • Stochastic Models of Zoonotic Avian Influenza with Multiple Hosts, Environmental Transmission, and Migration in the Natural Reservoir

    Sunday, December 15, 2024
    Author(s): Rowan L Hassman,Iona M H McCabe,Kaia M Smith,Linda J S Allen
    Source: Bulletin of mathematical biology
    Avian influenza virus type A causes an infectious disease that circulates among wild bird populations and regularly spills over into domesticated animals, such as poultry and swine. As the virus replicates in these intermediate hosts, mutations occur, increasing the likelihood of emergence of a new variant with greater transmission to humans and a potential threat to public health. Prior models for spread of avian influenza have included some combinations of the following components: multi-host...

  • Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice

    Tuesday, December 10, 2024
    Author(s): Kelsey M Smith,Sarah G Francisco,Ying Zhu,Tanya LeRoith,Meredith L Davis,Jimmy W Crott,Kathryn Barger,Andrew S Greenberg,Donald E Smith,Allen Taylor,Laxmi Yeruva,Sheldon Rowan
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    Oral antibiotic use is both widespread and frequent in older adults and has been linked to dysbiosis of the gut microbiota, enteric infection, and chronic diseases. Diet and nutrients, particularly prebiotics, may modify the susceptibility of the gut microbiome to antibiotic-induced dysbiosis. We fed 12-month-old mice a high glycemic (HG) or low glycemic (LG) diet with or without antibiotics (ampicillin and neomycin) for an additional 11 months. The glycemic index was modulated by the ratio of...